Health Care

What Is Bilateral Oophorectomy- A risk factor for dementia

What Is Bilateral Oophorectomy?

An oophorectomy has the advantage of minimizing the risk of ovarian cancer, but it is not without danger. Premature menopause, and hormone disruption, are caused by eliminating the ovaries, which can cause heart disease, osteoporosis, depression, as well as other issues. New research adds to the body of knowledge by demonstrating that oophorectomy is associated with a higher risk of dementia. Menopause, the journal of the North American Menopause Society, has released the study’s findings online today (NAMS).



Dementia is a condition in which a person’s mental abilities — thinking, remembering, as well as reasoning has deteriorated to the point where it interferes with daily living and activities. Some dementia patients lose control of their emotions, as well as their personalities shift. Dementia can range in intensity from the mildest stage, when it is just starting to damage a person’s ability to perform, to the most serious level, when the person is fully dependent on others for basic everyday routines.

Dementia becomes more common as people age (about one-third of all persons aged 85 and up may have some kind of dementia), but it is not a normal component of aging. Several people live well into their nineties and beyond without showing any signs of dementia.

Dementia affects women significantly, with a 55 percent increased risk from the age of 65 onwards than men. The fact that women live longer on average than men does not clearly explain this sex disparity.


Estrogen has long been suspected of being a contributing factor in women’s greater dementia incidence. That’s why oophorectomy, a common procedure that permanently changes sex steroid exposure, is suspected of being a female-specific dementia risk factor. In women who are at a higher genetic risk of ovarian cancer, bilateral oophorectomy (removal of both ovaries) is occasionally combined with hysterectomy to help avoid ovarian cancer.

Much previous research looked into the link between bilateral oophorectomy and dementia, however, the results were mixed. The purpose of this new study, which included over 25,000 women, was not only to look into the prospective link with oophorectomy as well as the likelihood of incident dementia, but also to see if the risk was modified by age at the time of surgery, hysterectomy, or hormone treatment use.

The study determined that bilateral oophorectomy, but not unilaterally oophorectomy, was linked to a higher risk of dementia. They were unable to establish if this link was dependent on hysterectomy or hormone treatment use. The result of the research is given in the publication “Oophorectomy and rate of dementia: a prospective cohort study.”


The finding is consistent with previous studies that show a link between oophorectomy as well as dementia. The article’s statistical power was weak, which could explain why age and hormone therapy use had no effect on this connection. Given the growing body of evidence linking oophorectomy before menopause to long-term negative consequences, risk-reducing oophorectomy should be reserved for women with high genetic cancer risk, according to the researchers.

The North American Menopause Society (NAMS) was established in 1989 and is North America’s premier nonprofit organization dedicated to improving the health and quality of life of all women in midlife and beyond via a better understanding of menopause as well as healthy aging.

NAMS is distinctively fit to serve as the definitive provider of health workers and service users for precise, unbiased news about menopause as well as healthy aging because of its multiple disciplines memberships of 2,000 leaders in the field, such as basic and clinical science specialists from medicine, nursing, sociology, psychology, nourishment, anthropology, epidemiology, pharmacy, as well as education.

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“These findings are in line with previous research that has found a relationship between oophorectomy and dementia.” The article’s statistical power was limited, which could explain why age and hormone therapy use had no effect on this connection. “Risk-reducing oophorectomy should be restricted to those women with an inherited higher risk for cancer,” said Dr. Stephanie Faubion, NAMS medical director, “considering the significant body of evidence demonstrating potential long-term detrimental consequences linked with oophorectomy before the usual age of menopause.”

People May Ask

Q- Does oophorectomy cause dementia?

A- Early oophorectomy has been linked to an increased risk of Alzheimer’s disease, other types of dementia, and cognitive decline in several studies. According to some study, using hormone treatment (HT) until you achieve menopause at a normal age may assist to mitigate this risk.

Q- Is a hysterectomy associated with accelerated aging?

A- A hysterectomy is a significant shift in your body. This type of surgery might produce hormonal shifts, which can result in a variety of adverse effects, depending on where you are in your menopause journey. A hysterectomy by itself has no effect on your hormones or aging.

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